Lemak di Perut Tercermin di Amygdala dan Orbitofrontal cortices

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News KeSimpulan.com – Kerutan lemak di perut anda tercermin di otak. Memiliki ukuran pinggang yang lebih besar dapat menyusutkan otak Anda.

Obesitas dikaitkan dengan peningkatan risiko diabetes tipe 2 yang juga diketahui terkait dengan gangguan kognitif. Antonio Convit di New York University School of Medicine ingin melihat apa dampak obesitas terhadap struktur fisik otak. Convit dan rekannya menggunakan pencitraan resonansi magnetik untuk membandingkan otak 44 penderita obesitas dengan dari 19 orang bertubuh langsing dengan usia dan latar belakang sama.

Para peneliti menemukan orang obesitas memiliki lebih banyak air di amigdala (bagian otak yang terlibat dalam perilaku makan), Selain itu orbitofrontal cortices (bagian penting untuk kontrol impuls dan juga terlibat dalam perilaku makan) lebih kecil dan melapor ke Brain Research:

Adiposity is associated with chronic low-grade systemic inflammation and increased inflammation in the hypothalamus, a key structure in feeding behavior. It remains unknown whether inflammation impacts other brain structures that regulate feeding behavior. We studied 44 overweight/obese and 19 lean individuals with MRI and plasma fibrinogen levels (marker of inflammation). We performed MRI-based segmentations of the medial and lateral orbitofrontal cortex (OFC) and hippocampal volumes. Gray matter (GM) volumes were adjusted for head size variability. We conducted logistic and hierarchical regressions to assess the association between fibrinogen levels and brain volumetric data. Using diffusion tensor imaging (DTI), we created apparent diffusion coefficient (ADC) maps and conducted voxelwise correlational analyses. Fibrinogen concentrations were higher among the overweight/obese (t[61] =−2.33, P = 0.023). Lateral OFC associated together with fibrinogen correctly classified those with excess of weight (accuracy = 76.2%, sensitivity = 95.5%, and specificity = 31.6%). The lateral OFC volumes of overweight/obese were negatively associated with fibrinogen (r =−0.37, P = 0.016) and after accounting for age, hypertension, waist/hip ratio and lipid and sugar levels, fibrinogen significantly explained an additional 9% of the variance in the lateral OFC volume (β =−0.348, ΔR2 = 0.093, ΔF P = 0.046). Among overweight/obese the associations between GM ADC and fibrinogen were significantly positive (P < 0.001) in the left and right amygdala and the right parietal region. Among lean individuals these associations were negative and located in the left prefrontal, the right parietal and the left occipital lobes. This is the first study to report that adiposity-related inflammation may reduce the integrity of some of the brain structures involved in reward and feeding behaviors.

"Ini bisa berarti ada neuron kurang atau neuron mereka yang menyusut," kata Convit.

"Jika Anda makan berlebih tampaknya menghasilkan perubahan saraf yang meningkatkan risiko untuk makan berlebihan di masa depan," kata Stice.

Eric Stice di Oregon Research Institute di Eugene, berpikir temuan mereka memperkuat "celah neurologis" tentang teori obesitas. Obesitas dikaitkan dengan peradangan, konstan tingkat rendah dimana Convit menjelaskan perubahan dalam ukuran otak.
  1. Fanny Cazettes, Jessica I. Cohen, Po Lai Yau (Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA); Antonio Convit (Department of Psychiatry, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA; Department of Medicine, New York University School of Medicine, 550 First Avenue, New York, NY 10016, USA; Nathan Kline Institute for Psychiatric Research, 140 Old Orangeburg Rd. Orangeburg NY 10962, USA) and Hugues Talbot (ISBS-ESIEE-Paris, BP 99 93162 Noisy-Le-Grand, France). Obesity-mediated inflammation may damage the brain circuit that regulates food intake, Brain Research, 10 December 2010, DOI:10.1016/j.brainres.2010.12.008
Antonio Convit http://www.med.nyu.edu/biosketch/convia01
Eric Stice http://www.ori.org/Research/scientists/sticeE.html
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